About

Acute coronary syndrome (ACS) is one of the most common health problems globally and a leading cause of death and signficiant morbidity in developed countries. It represents a clinical condition characterised by rapidly developing critical myocardial ischaemia. ACS encompasses three related but distinct clinical entities – unstable angina, non-ST-segment elevation MI (NSTEMI), and ST-segment elevation MI (STEMI).

Acute coronary syndromes are characterised by vascular inflammation, subsequent endothelial dysfunction and platelet activation, followed by thrombus formation. Uncontrolled thrombosis can culminate in complete vascular occlusion and STEMI.

Key diagnostic procedures for detection of patients with ACS are ECG at rest and markers of myocardial necrosis. Optical coherence tomography can be used to assess patients with ACS and is useful because it can detect plaques at high risk of rupture and provide additional information about plaque composition, thrombi and collagen. Troponin T and troponin I are specific cardiac markers for myocardial injury and diagnosing the myocardial necrosis.

Management of ACS should encompass both acute and long-term strategies.

What is Myocardial Infarction?

Also known as a heart attack, myocardial infarction (MI) is a necrosis of the heart muscle that originates from an acute obstruction of a coronary artery. It decreases blood flow and leads to irreversible damage to the heart due to myocardial ischaemia.

Articles

Best Practices in Pharmacotherapy for Acute Coronary Syndromes

Published:

01 July 2022

Citation:

US Cardiology Review 2022;16:e16.

Complete Revascularisation and Acute Unloading Prior to Percutaneous Coronary Intervention Increases Survival in Acute MI Cardiogenic Shock

Published:

28 June 2022

Citation:

Interventional Cardiology Review 2022;17(Suppl 1):18–9.

Treatment with Impella and Venoarterial Extracorporeal Membrane Oxygenation During Cardiac Arrest Improves Survival: A Multicentre Cohort Study

Published:

28 June 2022

Citation:

Interventional Cardiology Review 2022;17(Suppl 1):17–8.

Innovation Lecture: Current Understanding of the Molecular Mechanisms of Unloading and Recovery – Past, Present and Future

Published:

28 June 2022

Citation:

Interventional Cardiology Review 2022;17(Suppl 1):13–5.